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This specific combination has been researched to prove to activate multiple regenerative pathways simultaneously: GHK-Cu facilitates the copper uptake vital for collagen and elastin cross-linking

Incubation experiments demonstrated that E2 esterification and further association with LDL was able to increase LDL resistance to oxidation (276, 277)

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These investigators demonstrated in fibroblast culture that GHK-Cu strongly stimulated collagen synthesis, with the effect beginning at picomolar concentrations, maximizing near a nanomolar concentration, and occurring independently of any change in cell number a signature more consistent with specific signaling than with a generic growth push

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