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Future gene editing therapies and studies should consider utilizing delivery of gene editing therapies directly to specific organ(s) to improve outcomes [51,52,53] and overcome limitations of systemic delivery, such as generalized immune response to the viral vector [54]

Tirzepatide showed significant reductions in HbA1c and body weight compared to placebo

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These findings reveal a striking functional divergence: in microglia, SYK primarily drives phagocytosis [13, 15, 16], whereas in SCs, its paramount function centers on metabolic regulation