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The involvement of the cAMP-PKA pathway in the pathogenesis of psoriasis and PsA is further supported by the efficacy of PDE-4 inhibitors, with the European Medicines Agency (EMA) and Food and Drug Administration (FDA) having approved apremilast for the treatment of these conditions (8688)

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Strober W, Asano N, Fuss I et al (2014) Cellular and molecular mechanisms underlying NOD2 risk-associated polymorphisms in Crohns disease

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