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In another study, -Gal A-deficient endothelial cells showed the degradation of the glycocalyx by heparinases because of an inflammatory response and the authors suggested that this might explain the endothelial dysfunction observed in Fabry patients [61]

Treatment typically involves vitamin B12 supplementation, either through oral supplements or injections, depending on the severity of the deficiency and underlying causes.

doi: 10.1016/j.redox.2022.102292