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Rho GTPase complementation underlies BDNF-dependent homo- and heterosynaptic plasticity

It has been argued, in the broad context of synaptic plasticity at excitatory synapses, that an emphasis on [Ca 2+ ] i rise as the triggering mechanism of plasticity can offer improved explanatory value over a fixation on learning rules, such as STDP (Lisman and Spruston, 2+ ] i rise is strong local activation and local spread to inactive synapses or more global influx through voltage gated channels activated by back-propogating action potentials and amplified by release from internal stores

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Efficacy and safety of co-administered once-weekly cagrilintide 2.4 mg with semaglutide 2.4 mg in type 2 diabetes: a multicentre, randomised, double-blind, active-controlled, phase 2 trial Frias JP, Deenadayalan S, Erichsen L, et al

There is also a reduction in the formation of dendrites or extensions of melanocyte, the part of the cell that allows the melanosome to reach the keratinocytes in the epidermis