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The results of another study published in the Journal of the American College of Cardiology showed an increased risk of stiffness in the arteries was more likely to occur in participants who drank coffee and smoked in the same session

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Specifically, activation of the TRPA1 receptor could be significant in several pathological situations given that it is known to be stimulated by a multitude of environmental irritants (including constituents of air pollution and burning vegetation), as well as endogenous products of oxidation which can be generated in the airways by inhalation of pollutants or during inflammation (Bessac et al., 2008