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Conversely, after blocking the IGF-1 receptor (IGF-1R) in normal mice, the growth advantage conferred by the microbiota is diminished (250)

Antibodies binding to and directly stimulating the IGF-1R have also been proposed to play a role in this process

Follow up maintenance treatments aim to control residual tumor cells, but generally fail due to cross-resistance, inefficient targeting of tumor vulnerabilities, or dose-limiting toxicity, resulting in relapse and disease progression

Petrenko V, Gandasi NR, Sage D, Tengholm A, Barg S, Dibner C (2020) In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis