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This also explains why effects can outlast blood levels

When 5-Amino-1MQ inhibits NNMT, nicotinamide is preserved and available for NAD+ synthesis, leading to increased intracellular NAD+ concentrations

Vose J, Armitage J, Weisenburger D

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Cancer Cells NNMT is implicated in regulating tumor proliferation, invasion, and drug resistance by affecting multiple signaling pathways in vivo ( Figure 1 )