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[Crossref] [Google Scholar] [PubMed] Gltepe M, Ozcan O, Avar K, etin M, Ozdemir AS, Goka M, et al

So it's something that absolutely needs to be addressed

10.1038/nbt831 60 JacksonA

In these affected organs, NTBI is known to facilitate excessive Reactive Oxygen Species (ROS) generation exceeding the capacity of cellular antioxidant systems