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Body cell mass as reflected by intracellular water decreased -1.0 kg with placebo but increased 0.8 kg with MK-677 (P=0.021)

33 GLP-1 also reduces hepatic production of glucose by reducing the expression of key metabolic regulators of glycogenolysis

Tirzepatide is not recommended during pregnancy, particularly when used for weight management, and can reduce the effectiveness of oral contraceptives