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During the aggregation process of aSyn, oligomeric intermediates between monomers and large insoluble aggregates are formed, and these intermediates are believed to be toxic [5, 6]

PMID: 41812636 Nat Sci SleepThe Role of Ferroptosis in Adenoid Hypertrophy in Children with Obstructive Sleep Apnea Syndrome

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Appelboam AV, Dargan PI, Knighton J

2C that tryptophan fluorescence spectra has been red shifted followed by large reduction in fluorescence intensity at max indicating certain chromophore(s) that was buried in the core of the protein have been shifted to the polar environment