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Intriguingly, a study postulated that a moderate increase of ROS levels may play a role in redox homeostasis by protecting the cell through a preconditioning process, which posits that exposure to a small insult allows better tolerance of a subsequent larger insult

doi: 10.1038/s41598-018-21421-x 235

Unique gene expression profiles of human macrophages and dendritic cells to phylogenetically distinct parasites

However, if the amounts of acetyl-CoA generated in fatty acid -oxidation challenge the processing capacity of the TCA cycle or if activity in the TCA cycle is low due to low amounts of intermediates such as oxaloacetate, acetyl-CoA is then used instead in biosynthesis of ketone bodies via acetoacyl-CoA and -hydroxy--methylglutaryl-CoA (HMG-CoA)

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