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Key finding: AOD 9604 increased type II collagen synthesis by 180% and cartilage proteoglycan content by 156% in human OA chondrocytes

The most affected phenotype identified was that of Igfbp4 ko mice who were growth retarded at birth and displayed poor postnatal growth (30)

The Monash research program selected this specific fragment because animal-model studies reported it retained the lipolytic activity of full hGH without the growth-promoting effects mediated through the hGH receptor and IGF-1 axis

In FDA labeling, it works through incretin related pathways that affect appetite, food intake, and blood sugar control

The effects of a B12 injection can last around 1-2 months before another shot is needed