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Lifelong endurance training (more than 3 times/week) lower DNA methylation in 714 gene promoters, including those associated with glycolysis, glycogen metabolism, muscular dystrophies, and oxidative stress response in skeletal muscle of the elderly, potentially enhancing the expression of genes involved in muscle metabolism and myogenesis, while the methylation levels of introns, CpG islands and exons appear similar between physically active and inactive groups [132]

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The Glutathione Reduced antioxidant functions involves reusing vitamins E and C and serving as a crucial scavenger of nucleophilic to aid antioxidant of all types of tissues

Exp Biol Med (Maywood) (2008) 233:67488