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KLHL12, an E3 ubiquitin ligase adapter, targets Dvl for proteasomal degradation, negatively affecting the canonical Wnt pathway

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The process is initiated by a copper-mediated (and CCS1-independent) oxidative step, in which one of the SOD1 cysteine residues becomes sulfenylated

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doi: 10.1016/j.cmet.2020.10.011 98 JelinekAHeyderLDaudeMPlessnerMKrippnerSGrosseRet al

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