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Specific effects documented in research include proliferation of hair follicle progenitor cells, extension of the anagen (growth) phase of the hair cycle, increased hair follicle size and density, formation of new dermal papilla structures, enhanced wound-induced hair neogenesis, and prevention of follicle miniaturization

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Additionally, the N-terminal tryptophan is among the more oxidation-prone and light-sensitive residues

Safety and translational challenges are considerable and must drive clinical application: immune stimulation carries theoretical risk as well as known risk of worsening autoimmune phenomena or inflammatory toxicities, particularly in the setting of active immunosuppression (e.g., newly diagnosed with cytotoxic therapy, on high-dose steroids)