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It also establishes numerous hydrophobic interactions with His114(2), Phe117, Ala160, Leu163(2), Ala164, Leu170(3), Cys171(2), Ile197, Ile198(2), Ile315, Tyr325, Phe342, Tyr397, and Tyr434

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Despite these promnestic effect, the metabolism of sulfated neurosteroids, such as PregS by sulfatases, coupled with limited transport across the BBB, has impeded the development of this compound as a novel therapeutic