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Ghrelin O-acyltransferase (GOAT) and energy metabolism

By inhibiting NNMT, 5-Amino-1MQ may spare nicotinamide for NAD+ synthesis via the salvage pathway, thereby activating SIRT1 (Sirtuin 1) pathways associated with mitochondrial biogenesis, fat oxidation, and metabolic flexibility [3]

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Second, proteolytic enzymes throughout the gastrointestinal tract, including pepsin in the stomach, trypsin and chymotrypsin in the small intestine, and brush-border peptidases, cleave peptides into inactive fragments

Conversely, with the HCG diet, after the initial phase, there is little to no cravings for food