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Joint pain has also been reported by some users, particularly at higher doses

10.1016/j.ajpath.2019.09.012 119 ZhuH.HuangJ.ChenY.LiX.WenJ.TianM.et al (2022)

Despite knowledge of obesity-related complications in younger adults (increased risk of type 2 diabetes, liver and cardiovascular disease and malignancy), these considerations may be outweighed, in older adults, by concerns regarding weight-loss induced reduction in skeletal muscle and bone mass, and the awareness of the obesity paradox

When older liver cells were cultured in plasma from the younger group, their protein synthesis patterns shifted toward the younger profile