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1 Introduction Neurodegenerative diseases such as Alzheimers disease (AD), Parkinsons disease (PD), and multiple sclerosis (MS) are characterized by progressive nerve damage and chronic inflammation

Once inside the cell, Fe 3+ is reduced to Fe 2+ via six-transmembrane epithelial antigen of prostate 3 (STEAP3) and transported into the cytosol by divalent metal transporter 1 (DMT1) and ZRT/IRT-like proteins 8 and 14 (ZIP8/14) (Wang et al., 2025d)

Elevating levels of antioxidants can reduce damage due to oxidative and inflammatory stress, improving stem cell survival and efficacy

Reprogramming mitochondrial metabolism in synovial macrophages of early osteoarthritis by a camouflaged Meta-Defensome