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Grx2 was identified a little over a decade ago, shares ~34% sequence identity with Grx1, and is highly concentrated (~1 M in comparison to Grx1 which is ~0.1 M) in mitochondria (Gallogly et al., 2004)

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Discovery and Optimization of Novel Nonbile Acid FXR Agonists as Preclinical Candidates for the Treatment of Inflammatory Bowel Disease