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Jonine Jancey, Curtin University Despite their widespread reputation as a safer alternative to cigarettes, e-cigarettes (also known as electronic cigarettes or vapes) are far from harmless, particularly for adolescents, whose developing brains may suffer lifelong adverse effects from nicotine-containing products

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Cox proportional hazards models were used to estimate the hazard ratio (HR) for each outcome, adjusting for major cardiovascular risk factors and testing interactions between age at initiation and cumulative smoking exposure

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