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Pigmentation from hormonal causes such as melasma, and dark marks left by acne or post inflammatory hyperpigmentation, are different types of melanin deposits in different skin layers caused by different triggers

And the enhanced AO activity has been linked with decreased stress tolerance (Garchery et al., 2013)

Additionally, after review of CBE-endorsed measures, we were unable to identify any CBE-endorsed measures for LTCHs that meet the aforementioned requirements