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Although interactions between pharmacokinetic drugs and tobacco smoke are primarily attributed to PAHs rather than nicotine, the latter is significantly involved in pharmacodynamic interactions through the activation of the sympathetic nervous system ( Beyond PAHs and nicotine, other substances such as acetone, pyridine, heavy metals, benzene, and CO in tobacco smoke may also interact with hepatic enzymes, albeit their impact is considered less significant (Kroon, 2007)

[9] As Dobbins points out, a Fifth Circuit panels ruling upholding an MDO in Wages and White Lion Investments, d/b/a Triton Distribution v

Clarkson, Wensley (1993)

Mixing substances increases the likelihood of emotional problems and accidents

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