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This problem can be solved by using thiourea, (NH 2 ) 2 C=S, as the nucleophile

Disclosures: Laurent Castera: Nothing to Disclose, Ming-Lung Yu: Abbvie, Gilead and Roche diagnostics.: Grant/Research Support, Abbott, Abbvie, Gilead, Roche and Roche diagnostics: Consultant, Abbvie, BMS, Gilead, Roche and Roche diagnostics: Speaking and Teaching, Maria Buti: Nothing to Disclose, Nothing to Disclose, Jinlin Hou: Nothing to Disclose, Frida Abramov: Gilead Sciences, Inc: Employee, Gilead Sciences, Inc: Stock - publicly traded company, Hongyuan Wang: Nothing to Disclose, Ben Da: Nothing to Disclose, DANA TEDESCO: Gilead Sciences, Inc.: Employee, Leland Yee: Nothing to Disclose, John Flaherty: Nothing to Disclose, Harry Janssen: Gilead Sciences: and consultant, Gilead Sciences: Grant/Research Support, GlaxoSmithKline: Grant/Research Support, Janssen: Grant/Research Support, Roche: Grant/Research Support, Vir Biotechnology Inc.: Grant/Research Support, Aligos: Consultant, Gilead Sciences: Consultant, GlaxoSmithKline: Consultant, Grifols: Consultant, Roche: Consultant, Vir Biotechnology Inc: Consultant, Precision Biosciences: Consultant, Milan Sonneveld: Nothing to Disclose

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