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doi: 10.1007/s11596-018-1862-9

One possible explanation is that low serum vitamin B12 levels would trap folate as 5-methyltetrahydrofolate, prevent the generation of methionine from homocysteine, and therefore reduce protein synthesis and lean tissue deposition

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Higher absorption rate The intramuscular injection method ensures a 95% absorption rate compared to oral supplements, which have only 50% absorption