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Critical safety thresholds have been established for compounds like EGCG (800 mg/day limit) (240) and -carotene (contraindicated in smokers), while hepatotoxicity cases linked to curcumin formulations have prompted regulatory warnings across multiple jurisdictions

Freckman DW, Caswell EP

J Hematol Oncol 15:10 Peng B, Shi RF, Bian J, Li YW, Wang PP, Wang HL, Liao J, Zhu WG, Xu XZ (2021) PARP1 and CHK1 coordinate PLK1 enzymatic activity during the DNA damage response to promote homologous recombination-mediated repair

GPX4 deficiency also triggers ferroptosis in B1 and marginal zone (MZ) B cells, potentially contributing to tumorigenesis [121]

RESEARCH: Children with autism were significantly less likely to have been breastfed than those without autism