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[DOI] [PubMed] [Google Scholar] 102.Jiang T., Tian F., Zheng H., Whitman S.A., Lin Y., Zhang Z., Zhang N., Zhang D.D

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Another strategy to achieve early memory phenotypes is the use of pharmacological inhibitors targeting T-cell differentiation signaling pathways during the culture of CAR-T cells, such as phosphatidylinositol 3-kinase (PI3K) inhibitors (duvelisib) and Brutons tyrosine kinase inhibitors (ibrutinib) [62, 63]

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When mitochondrial homeostasis is shifted, these pathways become altered or shut down, likely contributing to the death of hepatocytes with activation of inflammation and hepatic stellate cells, causing liver fibrosis and cirrhosis