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Interestingly, -synuclein and other associated proteins like DJ-1, parkin, and LRRK2 play a perilous role in the activation of microglia (Calopa et al

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Mechanistic research has also linked DSIP to interactions with GABAergic and serotonergic signaling systems, which are critical for maintaining inhibitory tone and emotional regulation

However, it also heavily influences the flow of blood through the microcirculation, where blood acts as a thixotropic fluid, somewhat like toothpaste, flowing under increased pulses of blood pressure, then reverting to a semi-solid gel