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Natural materials, including silk fibroin (Zeng et al., 2014), fibrin (Huang et al., 2010), ECM (Yuan et al., 2022), alginate (Huang et al., 2011), and chitosan (Roughley et al., 2006) have demonstrated with biocompatibility and minimal cytotoxicity

Most research protocols use daily or every-other-day dosing, with administration timing synchronized to the active metabolic phase of the model (early light cycle for nocturnal rodents)

Immediately after the injury, patients need emergency care, most likely in an ER or an urgent care clinic

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