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After treatment with LNP, TM-LNP, or TL-LNP at 0.5 g mL 1 of mRNA in serum-free medium for 12 h

Avoid taking high-dose B6 supplements without consulting your doctor: While the daily upper limit is set at 100 mg pyridoxine, there have been reported cases of pyridoxine-induced neuropathy in people taking 25 to 50 mg per day for longer than six months

"Despite statements on your product labeling marketing your products for laboratory research purposes only and not for human consumption, medical use or veterinary use, evidence obtained from your website establishes that your products are intended to be drugs for human use," the agency wrote

doi: 10.1371/journal.pone.0048277 Wu J, Weening EH, Faske JB, et al

10.1186/s12711-015-0139-z 11 DanecekP.AutonA.AbecasisG.AlbersC