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However, we did not observe any amelioration of motor impairment in PARK2 knockout mice exposed to rotenone, although cognitive impairment was attenuated by etomoxir treatment (Fig

For example, FAD-free NQO1 or a cancer-associated P187S mutant form of NQO1 exhibits reduced FAD binding and is degraded by the ubiquitinproteasome system 53,60