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31 Predicting drug elimination based on half-life can go awry when very high doses of drugs are used, 32 as in the case of fluoxetine and the treatment of obsessive-compulsive disorder and when drugs are consumed in overdose

We are finalizing as proposed in section II.G.2 of this final rule to make payment for advanced primary care management (APCM) services furnished by a physician or other qualified health care professional who is responsible for all primary care (for example, physicians and non-physician practitioners, including nurse practitioners, physician assistants, certified nurse-midwives and clinical nurse specialists), and serve as the continuing focal point for all needed health care services during a calendar month

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Studies examining the early treatment of AIH, the most active period of drug titration, are limited in part due to difficulties in reliably pinpointing the date of diagnosis in large electronic health records