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A well-known study from UCLA found that B12 supplementation alters the gene expression of C- acnes (formerly P-acnes ), the bacterium linked to acne

Human oral bioavailability has not been established

Avoid layering peptides with high-strength AHAs or BHAs, strong Vitamin C, retinoids, and low-pH exfoliants, as they may reduce peptide activity and could cause irritation in some cases.

Regular monitoring of blood B12 levels and patient response

However, with the current environments we live in and the poor quality and mass production of food, especially animal products at the moment, everyone is at risk of having below sufficient levels of Vitmain B12