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Extracellular ATP has been certified to modulate the expression of P2X7 receptors on APCs in cancer [147, 148]

Melatonin is an antioxidant, anti-inflammatory, free radical scavenger, circadian rhythm regulator, and sleep hormone ( 2 The placenta 2.1 Overview The placenta is a multifaceted, temporary organ with numerous biological functions largely considered endocrinologic and immunologic ( 2.2 Development The formation of the placenta begins after the fertilized egg is implanted into the uterus, which occurs approximately 8 to 10 days after conception ( The placenta comprises two distinct sides, the maternal and the fetal sides ( Figure 1 )

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