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Furthermore, microRNA sequence analysis showed that IMSC-SEVs were highly enriched in miR-105-5p, which had a pivotal role in the IMSC-SEV-mediated therapeutic effect by downregulating the level of cAMP-specific hydrolase PDE4D and leading to SIRT6 activation [95] (Table 7)

Your physician or surgeon may not feel you need to take the extra steroid at the time of surgery, but if they know you have been on corticosteroids they can watch you more carefully after surgery

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