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This equilibrium is particularly critical in high-energy-demand tissues, such as the heart, where copper serves as an indispensable cofactor for key metabolic enzymes and mitochondrial function [18, 19]

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152 Dysregulation of Wnt/-catenin signalling is often caused by mutations of various components in the pathway, particularly mutations or silencing of the Wnt tumour suppressor, which occurs frequently in various cancer types, such as adenomatous polyposis coli (APC) mutations, 193 Axin1/2 mutations, 194,195 GSK3 deletions, 196 inactivation mutations of E3 ubiquitin ligase RNF43, 196 and Znrf3

Specific genetic disorders like Turner syndrome and Klinefelter syndrome result in infertility because they involve chromosomal irregularities