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A phase 1 trial in healthy volunteers showed promising tolerability and dose-dependent methionine reduction (84)

On the other hand, the expression of various male reproductive genes, such as testis-related transcription factors (Sox9a and wt1), was suppressed by endosulfan (Rajakumar et al., 2012), while BPA is nonsteroidal with binding affinity for estrogen receptors, ER and Er (Welshons et al., 2003)