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No significant alterations were found in plasma levels of liver transaminases AST (28.22 7.30 and 39.40 7.20) and ALT (18.52 5.33 and 20.59 8.29) in control and pravastatin treated LDLr -/- mice, respectively

Opportunistic or pathogenic bacteria that produce GUSs often exist at a low level in healthy gut microbiota 26

Potential mechanisms include: Alterations in methylation pathways Changes in NAD+ availability Mild dehydration secondary to metabolic shifts Headaches are generally mild but may become persistent in sensitive individuals

Most importantly, ER is suggested to play a key role in regulating the metabolism of BCSCs, given several glycolysis-related pathways are upregulated in ER-activated mammospheres (214)

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