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Clinically, metformin has been shown to mitigate the risk of CVD in diabetic patients, while preclinical studies have demonstrated its efficacy in enhancing cognitive function in AD murine models

The answer depends on the form of glutathione and how it is processed and packaged

Feb 2022;156:1-11

However, the endoplasmic reticulum, with GSH:GSSG ratios ranging from 1:1 to 3:1, provides a much more oxidizing environment to allow oxidative protein folding