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Alternative medicine [edit] With the growth of direct-to-consumer genetic testing, the alternative medicine industry has aggressively targeted a range of dubious tests [43] and highly profitable quack treatments for claimed MTHFR polymorphisms, despite the lack of any demonstrated health effects of these mutations

This effect seems to be independent of mu opioid peptide receptors (MOP), as it was not reversed by the MOP antagonist naltrexone, nor mimicked by the MOP agonist methadone [65]

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A p-value less than 0.05 was considered statistically significant