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Noradrenergic neurons dwelling in the locus coeruleus are sensitive to various pathological insults and become altered or malfunctional in many neurological disorders, including attention-deficit/hyperactivity disorders, sleep-associated disturbances 591 , congenital central hypoventilation syndrome, depression and anxiety, and in neurodegenerative diseases, including AD and PD 592,593

Zhang W, He Q, Chan LL, Zhou F, El Naghy M, Thompson EB, Ansari NH: Involvement of caspases in 4-hydroxy-alkenal induced apoptosis in human leukemic cells

Modified ketogenic diet is associated with improved cerebrospinal fluid biomarker profile, cerebral perfusion, and cerebral ketone body uptake in older adults at risk for Alzheimer's disease: a pilot study

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Presumably the deficiency in regulatory T lymphocytes contributes to the elevated IgE levels