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In vivo antitumor assay All animal operations followed the guidelines of the Institutional Animal Care and Use Committee (IACUC) of the Animal Experiment Center of the Chinese University of Hong Kong (Shenzhen, China, protocol number, CUHKSZ-AE2022004)

Histone Kla is significantly increased on the promoters of M2-like genes in the later stage of stimulated M1 macrophage polarization, suggesting that histone Kla probably acts as a lactate clock to promote the switch from an inflammatory phenotype to a steady-state phenotype in macrophages

Moreover, ferroptosis, which occurs in tumor cells, can spread to neighboring cells via the paracrine release of lipid peroxides (Nishizawa 2021)

A primary concern is the scarcity of comprehensive in vivo studies and clinical trials

Iron exchange in the mitochondria is mediated by DMT-1 and classical mitoferrins (Mfrn) 1 and 2 [38], which are incorporated into the electron transport chain and produce ATP under the stimulation of glucose