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Chronical consumption (8 weeks) of a pure arabica dark-roast coffee blend significantly reduced spontaneous DNA strand breaks in blood cells of healthy volunteers, pointing to a DNA protective effect (Pahlke, 2019) and (Schipp 2018)

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Loading RU.521 to cNPs resulted in a profound reduction in ifnb, Nos2 , and Tnfa in macrophages, indicating the enhanced inhibitory effects on cGAS activation and pro-inflammatory responses (101)