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Controlling the SARS-CoV-2 spike glycoprotein conformation Nature Structural & Molecular Biology2020Henderson, R

After neutralizing a threat, oxidized glutathione can be converted back to its active form through an enzyme called glutathione reductase

In BV2 microglial cells, BV2-metformin-loaded PLGA treatment downregulated inducible nitric oxide synthase (iNOS) expression (proinflammatory M1 phenotype) and upregulated mannose receptor (CD206) expression (anti-inflammatory M2 phenotype), leading to a more than three-fold elevation in the CD206/iNOS fluorescence intensity ratio

Gong L, Shen X, Huang N, Wu K, Li R, Liu Y, Zhang H, Chen S, Sun R

Inhibition of cardiac apoptosis by trimetazidine (2.5 mg/kg acute pre-treatment) was replicated in swine with myocardial infarction [155]