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The apparent permeability coefficients (P app ) were calculated as described previously [40] with the following equation: where [C] A is the concentration difference of in the acceptor compartment at 24 h, [C] D is the concentration in the donor compartment at 0 h, V A is the volume of the acceptor compartment (0.9 ml), and A is the surface area available for permeability (0.33 cm 2 )

In addition to pharmacological control, recent studies have revealed that, owing to the pathogenic role of mitochondrial abnormalities in diabetes, transferring healthy mitochondria to pancreatic -cells to increase their insulin secretion function has emerged as a therapeutic strategy 552 and has garnered significant attention

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