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Secondly, aging contributes to heightened hyperexcitability in cortical networks, consequently escalating the energy requirements for axonal propagation of action potentials and synaptic neurotransmitter release [80,81]

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Babulal GM, Ghoshal N, Head D, Vernon EK, Holtzman DM, Benzinger TLS, et al

This sustained WBC elevation can reflect the activity or severity of the underlying disease and sometimes guides treatment decisions

261 Several PMO-based NADs have been approved for treating DMD, including eteplirsen (Exondys 51), 262 golodirsen (Vyondys 53 ), 80 viltolarsen (Viltepso ), 263 and casimersen (Amondys )