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FeSOD-A gene amplification increases the FeSOD protein expression and enzyme activity in a induced resistance to benznidazole and gentian violet treatments [73]

In particular, we focused on the p21 N-terminal cyclin-CDK binding domain, required for inhibition of G1/S cell cycle progression, and the C-terminal PCNA binding domain involved in suppressing DNA synthesis (Chen et al, 1995) (Fig 2D)