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The TMD of cytochrome P450 family 51 subfamily A member 1 (CYP51A1) has been demonstrated to be dependent on RNF185 for substrate recognition, 100 in which degrons in both the ER lumen and the TMD are needed, indicating that substrate selection is governed by multiple determinants as part of ERAD fidelity

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10.1016/s1474-4422(03)00306-5 105 VincentA.LeiteM