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Loss of ATRX, genome instability, and an altered DNA damage response are hallmarks of the alternative lengthening of telomeres pathway

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Worldwide, RSV affects more than 70% of infants in the first year of life, and nearly 100% of children by 2 years of age ( Scientific evidence has shown that after the resolution of respiratory diseases associated with RSV infection, the virus interferes with the establishment of immunological memory, which leads to recurrent reinfections ( RSV was first isolated in 1956, from throat samples in a colony of chimpanzees that had symptoms such as coughing, sneezing, and purulent nasal discharge ( This respiratory virus was recently classified in the Pneumoviridae family, Orthopneumovirus genus ( A growing concern is that severe RSV infection at an early age, may adversely affect pulmonary development and lead to long-term respiratory disorders